Antiviral effect of interferon in patients with chronic hepatitis C who were treated with short term(4-6 weeks) interferon.

• AKAHANE Yoshihiro

  First Department of Internal Medicine, Yamanashi Medical College

• OKADA Shunichi

  First Department of Internal Medicine, Yamanashi Medical College

• MIYAZAKI Yoshiki

  First Department of Internal Medicine, Yamanashi Medical College

• AINOTA Takao

  First Department of Internal Medicine, Yamanashi Medical College

• NAITO Shigeko

  First Department of Internal Medicine, Yamanashi Medical College

• SUZUKI Hiroshi

  First Department of Internal Medicine, Yamanashi Medical College

• SODEYAMA Takeshi

  Second Department of Internal Medicine, Shinshu University School of Medicine

• NAKANO Yoshiyuki

  Second Department of Internal Medicine, Shinshu University School of Medicine

• KIYOSAWA Kendo

  Second Department of Internal Medicine, Shinshu University School of Medicine

• FURUTA Seiichi

  Second Department of Internal Medicine, Shinshu University School of Medicine

• TSUDA Fumio

  Section of Immunology, Kitasato Institute

• OKAMOTO Hiroaki

  Immunology Division, Jichi Medical School

Bibliographic Information

Other Title

• Ｃ型慢性肝炎に対するｉｎｔｅｒｆｅｒｏｎの短期投与の抗ウイルス効果

Abstract

We have assayed HCV RNA levels, anti-CP-9 and anti-C100-3 in serial serum samples from 12 patients with chronic hepatitis C who were treated with short term (4-6 weeks) interfelon. In six patients, serum ALT levels fell to normal and remained in normal range after termination of treatment (effective group). The ALT levels did not improve in other six patients (non-effective group).<BR>Serum HCV RNA decreased markedly in all patients belonged to both groups at the end of treatment. In effective group. HCV RNA in serum sustained (-) or (+) after stopping interferon, but HCV RNA in serum returned gradually or rapidly to pre-treatment levels ( - ) in non-effective group. These observations suggest that interferon seems to suppress HCV RNA in serum and interferon treatment may improve natural course of chronic hepatitis C.

Journal

• Kanzo

  Kanzo 32 (3), 243-249, 1991

  The Japan Society of Hepatology

Keywords

• HCV RNA
• two-stage PCR

Details

• CRID: 1390001204791296128
• NII Article ID: 130000878273
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.32.243
• ISSN: 18813593
• ISSN: 04514203
• Web Site: http://www.jstage.jst.go.jp/article/kanzo1960/32/3/32_3_243/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1992081213
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed