急性肝不全で発症した成人Ｔ細胞白血病の１剖検例

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  • A case of adult T-cell leukemia (ATL) developed acute hepatic failure as the initial manifestation.

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A 58 year-old male patient with ATL developed acute hepatic failure as the initial manifestation is reported. The patient was admitted to our hospital because of hepatic coma (grade V) and subcutaneous bleeding in March 1988. Total bilirubin in serum was 4.8mg/dl, GOT 2093 IU/L, GPT 814 IU/L and NH3 350μg/dl. The leukocyte count in peripheral blood was 43, 600/mm3, consisted of 41% abnormal lymphocytes showing convoluted or lobulated nuclei. Serum anti-ATLA antibody was positive and HBs antigen was also positive. By the therapy for acute hepatic failure and chemotherapy for ATL, he recovered from the coma on the 8th hospital day with a decrease of peripheral leukocyte count. However, he suffered from sepsis on the 36th hospital day and died on the 45th hospital day. The pathological examination of the liver in autopsy revealed post-hepatitic liver cirrhosis accompanied with the infiltraiton of the ATL-cells in the portal area.

収録刊行物

  • 肝臓

    肝臓 30 (9), 1026-1031, 1989

    一般社団法人　日本肝臓学会

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