慢性肝炎の経過中に出現する亜広範性肝壊死に関する臨床病理学的検討

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  • Studies on submassive hepatic necrosis in patients with chronic active hepatitis.

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As pattern of hepatic cell necrosis in patients with chronic hepatitis (CH), focal necrosis, piecemeal necrosis and bridging necrosis have been reported. However, little is known about submassive necrosis appeared during the course of in CH. Four patients (2, CH type B, 1, CH type non-B, early liver cirrhosis), were examined by peritoneoscopy and liver biopsy, before and after severe exacerbation (total bilirubin 26.7±18.3mg/dl, GOT 1053±943 IU/l, Normo test 16±4.7%). All cases were negative for IgM anti-hepatitis A virus antibody. And, in 3 cases with HBs antigen positive chronic liver diseases, activity of HBV-DNA polymerase increased and anti-δ antibody was negative, anti-HBe antibody was positive.<BR>Histological study of the liver biopsy specimens taken from the liver after the exacerbation showed the presence of submassive necrosis and rosette formation of liver cells. These liver were progressed to postonecrotic liver cirrhosis. Our observations clearly demonstrate that the patients with CH having submassive hepatic necrosis developed atrophic liver cirrhosis, later.

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  • 肝臓

    肝臓 28 (9), 1157-1163, 1987

    一般社団法人　日本肝臓学会

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