ヒト肝癌細胞株によるＡｍｉｎｏｔｅｒｍｉｎａｌ　ｐｅｐｔｉｄｅ　ｏｆ　Ｔｙｐｅ　ＩＩＩ　Ｐｒｏｃｏｌｌａｇｅｎの産生

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  • Production of aminoterminal peptide of type III procollagen by established human hepatoma cell lines.

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One cell line from human hepatoma, PLC/PRF/5, was found to produce type III procollagen, while four other ones, huH-1, huH-4, Huh-6c15 and Huh-7, were not. For the assay of aminoterminal peptide of type III procollagen, a radioimmunoassay was used. The productive rate of this peptide by PLC/PRF/5 was one-fortieth of that of human embryonal fibroblasts. The spent media of the above hepatoma cell lines showed stimulative activity on human embryonal fibroblast for collagen synthesis, and the activity remained in the nondialyzable fraction.<BR>The surrounding tissue composed of fibroblasts might be mainly responcible for the increase of this peptide in the sera of patients with liver cancer.

収録刊行物

  • 肝臓

    肝臓 27 (9), 1290-1295, 1986

    一般社団法人　日本肝臓学会

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