-
- 古賀 郁利子
- 久留米大学第2内科
書誌事項
- タイトル別名
-
- Anti-cholestatic and cytoprotective properties of ursodeoxycholic acid. Studies in vivo and vitro.
- Studies in vivo and vitro
- 細胞膜保護作用について
この論文をさがす
抄録
In order to show the beneficial effect of urosodeoxycholic acid (UDCA) administration to patients with intrahepatic cholestasis, UDCA was given to intrahepatic cholestasis rat models and primary cultured rat hepatocytes.<BR>Oral administration of UDCA (20mg/kg) to rats with 17α-ethynyl estradiol-induced cholestasis improved biliary excretion of indocyanine green injected intravenously. Cytochemical study showed a better preservation of alkaline phosphatase in the bile canalicular membrane in UDCA treated rat.<BR>In cultured rat hepatocytes, the cytotoxicity induced by taurochenodeoxycholic acid was compromised by increasing the UDCA concentration in culture medium.<BR>These findings suggest that UDCA hampered the development of cholestasis by 17α-ethynyl estradiol and this effect was thought to be brought by the cytoprotective effect of UDCA against the CDCA induced cytotoxicity during the course of cholestasis.
収録刊行物
-
- 肝臓
-
肝臓 28 (12), 1597-1604, 1987
一般社団法人 日本肝臓学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204790888960
-
- NII論文ID
- 130000881243
-
- COI
- 1:CAS:528:DyaL1cXhsl2qs7c%3D
-
- ISSN
- 18813593
- 04514203
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可