重症アルコール性肝炎の臨床的・病理学的検討

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  • Clinical and pathological studies in severe alcoholic hepatitis.

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Clinical and histological features in 8 cases with severe alcoholic hepatitis (SAH) were analysed and compared with those in 65 cases with non-severe alcoholic hepatitis (AH).<BR>All of 8 cases with SAH had less than 50% of prothrombin value, 7 cases with SAH showed hepatic encephalopathy and 7 cases died of complications such as pneumonia, renal failure and gastro-intestinal bleeding within one month after the abstinence.<BR>All cases with SAH showed remarkable hepatomegaly above 2 FB under the right costal margin and leucocytosis above 10, 000/mm3.<BR>4 of 7 cases with SAH had fever, elevated serum BUN and creatinine levels.<BR>Endotoxemia was found in all cases with SAH examined.<BR>Circulatory immune complex was also frequently detected in cases with SAH.<BR>Hepatic scintigram using 99mTc-Phytate showed remarkably decreased hepatic uptake of radioisotope in cases with SAH.<BR>It was suggested that SAH had depressed reticulo-endothelial function which resulted in endotoxemia and multiple organ failure.

収録刊行物

  • 肝臓

    肝臓 28 (3), 297-304, 1987

    一般社団法人 日本肝臓学会

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