Therapeutic Effects of Bovine Enterovirus Infections on Autochthonous Rat Ovarian Carcinomas Induced by 7,12-dimethylbenz (a) anthracene (DMBA).
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- HACHIYA NAOKI
- Department of Virology, Kurume University School of Medicine
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- CHINAMI MASANOBU
- Department of Virology, Kurume University School of Medicine
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- SHINGU MASAHISA
- Department of Virology, Kurume University School of Medicine
抄録
It has been previously reported that infection by a bovine enterovirus (MZ-468), which does not infect normal human cells, was remarkably effective for the therapy of adult T cell leukemia (ATL) in experimental rabbit models (Shingu et al. 1991). Therapeutic treatment studies were performed twice on 30 and 20 autochthonous rat ovarian carcinomas induced by DMBA. The average tumor size of the virus treatment group was significantly smaller than the control group when analyzed by a nonparametric Mann-Whitney method (p<0.06 and 0.002 for the 1st and 2nd experiments, respectively). These results indicate that an enterovirus infection may be clinically useful for the therapy of human ovarian cancers with bad prognoses.
収録刊行物
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- Ｔｈｅ Ｋｕｒｕｍｅ Ｍｅｄｉｃａｌ Ｊｏｕｒｎａｌ
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Ｔｈｅ Ｋｕｒｕｍｅ Ｍｅｄｉｃａｌ Ｊｏｕｒｎａｌ 41 (4), 171-175, 1994
久留米大学医学部 The Kurume Medical Journal 編集部