Effect of N-(N-(L-trans-3-carboxyoxirane-2-carbonyl)-L-leucyl)-3-methyl-butylamine (E64C), a thiol-protease inhibitor, on tyrosine release from skeletal muscle cells.

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  • KOHAMA Kazuhiro
    Department of Pharmacology, Faculty of Medicine, University of Tokyo
  • MITANI Shohei
    Department of Pharmacology, Faculty of Medicine, University of Tokyo
  • SHIRAO Tomoaki
    Department of Pharmacology, Faculty of Medicine, University of Tokyo

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Low concentrations (μg/ml level) of N-[N-(L-trans-3-carboxyoxirane- 2-carbonyl)-L-leucyl]-3-methyl-butylamine (E64C), a thiol-protease inhibitor, inhibited tyrosine release from skeletal muscle cells in which tyrosine release had been enhanced. Increase in cytoplasmic Ca2+ concentration seemed to be one of the factors that promoted the tyrosine release. These findings were discussed in relation to the mode of the protein degradation in the cells by thiolproteases including calcium-activated neutral protease.

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