Microbial metabolites with inhibitory activity against lipid metabolism

• TOMODA Hiroshi

  Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University

• NAMATAME Ichiji

  Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University Japan Society for the Promotion of Science

• OMURA Satoshi

  Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University

抄録

Microbial products inhibiting lipid metabolism, particularly involved in the fatty acid and cholesterol metabolic pathways were screened with various assay systems. Inhibitors were discovered for fatty acid synthase, acyl-coenzyme A (CoA) synthetase and diacylglycerol acyltransferase in fatty acid metabolism and 3-hydroxy-3-methylglutaryl-CoA synthase, acyl-CoA:cholesterol acyltransferase and cholesteryl ester transfer protein in cholesterol metabolism.

収録刊行物

• Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 78 (8), 217-240, 2002

  日本学士院

キーワード

• Microbial metabolite
• enzyme inhibitor
• screening system
• fatty acid metabolism
• cerulenin
• triacsin
• hymeglusin
• pyripyropene
• beauveriolide

詳細情報

• CRID: 1390282679124003968
• NII論文ID: 130000907744
• NII書誌ID: AA00785485
• DOI: 10.2183/pjab.78.217
• ISSN: 13492896
• ISSN: 03862208
• NDL書誌ID: 6366993
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6366993
• Web Site: http://www.jstage.jst.go.jp/article/pjab1977/78/8/78_8_217/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003143781
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可