Parvalbumin-like immunoreactivity in the human central auditory system.

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A calcium-binding protein, parvalbumin, was purified from the skeletal muscle of the Mongolian gerbil and a polyclonal antibody was raised against it in a rabbit. The antibody reacted with muscle parvalbumins from the gerbil and the rat and also with a protein in an extract of gerbil brain that had the same molecular weight as the muscle parvalbumins. Immunohistochemical localization revealed that this antibody bound to antigens in the neurons of the cerebral cortex, hippocampus and cerebellum of the human brain in a similar manner to its binding to parvalbumin-positive neurons in the corresponding areas of the rodents' brains. This antibody was also used in an immunohistochemical study of the central auditory system of the human brain. In the auditory pathway, the nervus vestibulocochlearis, striae acusticae, nuclei cochlearis ventralis et dorsalis, nucleus medialis olivaris superioris, lemniscus lateralis, nuclei lemniscus lateralis ventralis et dorsalis and colliculus inferior were found to contain immunopositive neurons and/or fibers. The nucleus lateralis olivaris superioris and nucleus medialis corporis trapezoidei in the human are difficult to localize. The antibody against parvalbumin stained two areas that seemed to correspond to the human homologs of these areas. Thus, in the human brain, the parvalbumin-specific antibody seems to be useful for the detection of the pathway of the central auditory system from the nervus vestibulocochlearis to the colliculus inferior. Such an antibody may also permit an examination of the correlation between the level of parvalbumin and the auditory functions within this pathway.

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