Development of New Composite Tissue Allotransplantation Models using supermicrosurgery
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- Yamamoto Takumi
- Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
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- Mihara Makoto
- Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
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- Narushirna Mitsunaga
- Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
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- Koshima Isao
- Department of Plastic Surgery and Reconstructive Surgery, The University of Tokyo
Bibliographic Information
- Other Title
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- Medical Care (Immunology, Transplantation Therapy, Regenerative Medicine, Reconstructive Surgery, Health Care Economy* Welfere and Politics and Military
Abstract
Currently, the composite tissue allotransplantation (CTA) is used clinically. However, side effects due to the immunosuppressant agents not for critical grafting become a major issue. Immunological tolerance introduced by the bone marrow transplantation (BMT) is an innovative therapy enabling long survival of a graft without immunosuppressant agents. We developed a new CTA model in order to apply the immunological tolerance introduction to the CTA. We prepared a rat lower limb transplantation model, a toe transplantation model, a forearm transplantation model, and mouse thigh chimera CTA model using supermicrosurgical technique. Additionally, we prepared a swine mandible CTA model in order to apply the technology to humans showing it is useful and with a wide clinical application. The CTA models developed by us do not include bones containing a lot of marrow (i.e., femur, humerus). They are superior CTA models that can evaluate the effect of immune tolerance by BMT.
Journal
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- Academic Collaborations for Sick Children
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Academic Collaborations for Sick Children 4 (1), 16-20, 2011
Japan Academic Collaboration Medical Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205320993664
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- NII Article ID
- 130000941663
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- ISSN
- 18845002
- 1884426X
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed