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- MAEDA TSUYOSHI
- The Department of Medicine, Nippon Steel Corporation Muroran Works Hospital
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- ASHIE TAKESHI
- The Department of Medicine, Nippon Steel Corporation Muroran Works Hospital
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- KIKUIRI KUNIYASU
- The Department of Medicine, Nippon Steel Corporation Muroran Works Hospital
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- TAKAKURA MASAYUKI
- The Department of Medicine, Nippon Steel Corporation Muroran Works Hospital
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- HIKITA NOBUICHI
- The Second Department of Internal Medicine, Sapporo Medical College
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- NAKAGAWA HIDEHISA
- The Second Department of Internal Medicine, Sapporo Medical College
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- SHIMAMOTO KAZUAKI
- The Second Department of Internal Medicine, Sapporo Medical College
抄録
A 40 year-old man was admitted to our hospital for detailed examination of hypokalemia (2.7mEq/l). His blood pressure was normal. Metabolic alkalosis, ACTH dependent hyperaldosteronism (18ng/dl) and over-response to synthetic ACTH were observed. Plasma renin activity, on the other hand, was within the normal range (1.7ng/ml/hr). Serum potassium was normalized to 4.1mEq/l and the responsiveness of the renin-angiotensin-aldosterone system was recovered after the administration of dexamethasone. These results led us to suggest that this case might be normotensive glucocorticoid-suppressible hyperaldotseronism. The etiology which was not associated with hypertension and low plasma renin activity has not been clarified but may be related to the shortness of duration of this disease. Our case was also afflicted with mild hypercortisolemia and excessive excretion of urinary 17-hydroxycorticosteroid and 17-ketosteroid which was suppressed by the administration of dexamethasone (2mg/day). These findings may be related to hypersensitivity of the fascicullar zone of the adrenal gland to ACTH.
収録刊行物
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- Ｅｎｄｏｃｒｉｎｏｌｏｇｉａ Ｊａｐｏｎｉｃａ
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Ｅｎｄｏｃｒｉｎｏｌｏｇｉａ Ｊａｐｏｎｉｃａ 36 (6), 817-825, 1989
一般社団法人 日本内分泌学会