Plasma Growth Hormone Responses to Growth Hormone-Releasing Factor in Normal Children and Children with Short Stature

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  • SUWA SEIZO
    Division of Endocrinology and Metabolism, Department of Pediatrics, Kanagawa Children's Medical Center
  • KATSUMATA NORIYUKI
    Division of Endocrinology and Metabolism, Department of Pediatrics, Kanagawa Children's Medical Center
  • MAESAKA HATAE
    Division of Endocrinology and Metabolism, Department of Pediatrics, Kanagawa Children's Medical Center
  • KUSAHANA ATSUKO
    Division of Endocrinology and Metabolism, Department of Pediatrics, Kanagawa Children's Medical Center
  • YAMADA YUMI
    Division of Endocrinology and Metabolism, Department of Pediatrics, Kanagawa Children's Medical Center

抄録

Plasma GH responses to GRF have been studied in 12 normal prepubertal children (6 boys and 6 girls) with normal height, 6 normal young adults and 90 patients with short stature due to various causes. Mean peak GH responses in normal boys and girls were 36±9ng/ml (M±SE) and 33±5ng/ml respectively. Among 25 patients with idiopathic severe pituitary dwarfism, 16 cases showed peak GH to GRF less than 5ng/ml, 3 cases between 5 and 10ng/ml and 6 more than 10ng/ml. There was a negative correlation between chronological age and peak GH responses to GRF in these 25 pituitary dwarfism. However, no correlation was observed in patients with partial idiopathic dwarfism (6 cases), normal short children (31 cases) and normal children. GH responses to GRF were blunted in organic pituitary dwarfism and primary hypothyroidism, but normal in deprivation dwarfism and Turner's syndrome. The responses in normal short children were variable, some children showed blunted but some normal. Acute exogenous GH administration suppressed the responsiveness of somatotrophs to GRF, but this was easily reversible even after chronic administration of GH for one year in normal short children who showed increased growth rate during the GH treatment.

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