Imaging and uptake mechanism of 131I-meta-iodobenzylguanidine in medullary thyroid carcinoma.

• OISHI SEIICHI

  Third Department of lnternal Medicine, University of Kumamoto

• SASAKI MASATO

  Third Department of lnternal Medicine, University of Kumamoto

• SATO TATSUO

  Third Department of lnternal Medicine, University of Kumamoto

• HIROTA YOSHIHISA

  Department of Radiology Faculty of Medicine, University of Kumamoto

• TAKAHASHI MUTSUMASA

  Department of Radiology Faculty of Medicine, University of Kumamoto

抄録

¹³¹I-meta-iodobenzylguanidine (¹³¹I-MIBG) was also taken up by medullary thyroid carcinoma (MTC) as well as by pheochromocytoma in two patients with Sipple's syndrome. However, the mechanism of ¹³¹I-MIBG uptake by MTC has not been clarified yet. We measured tissue catecholamine levels in three MTC, since MTC can produce several active substances. Catecholamines were detected in various amounts in all MTC, but not in normal thyroid tissues. These finding suggest that MTC can produce catecholamines and therefore, ¹³¹I-MIBG is taken up and stored in catecholamine vesicles of MTC, like pheochromocytoma and neuroblastoma. We conclude that ¹³¹I-MIBG may be applied not only to diagnosis but also for the treatment of patients with MTC.

収録刊行物

• Ｅｎｄｏｃｒｉｎｏｌｏｇｉａ　Ｊａｐｏｎｉｃａ

  Ｅｎｄｏｃｒｉｎｏｌｏｇｉａ　Ｊａｐｏｎｉｃａ 33 (3), 309-315, 1986

  一般社団法人 日本内分泌学会

キーワード

• General Engineering
• Endocrinology

詳細情報

• CRID: 1390001206298033152
• NII論文ID: 130000953278
• DOI: 10.1507/endocrj1954.33.309
• ISSN: 21856370
• ISSN: 00137219
• PubMed: 2875869
• Web Site: http://www.jstage.jst.go.jp/article/endocrj1954/33/3/33_3_309/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1988051106
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可