ACTH secretion during sleep in a patient with Nelson′s syndrome(Note)

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  • YOSHIDA KOICHIRO
    Department of Medicine, the Second Tokyo National Hospital and School of Medicine, Keio University
  • SATO AKIO
    Department of Medicine, the Second Tokyo National Hospital and School of Medicine, Keio University
  • YAMAGUCHI YOICHI
    Department of Medicine, the Second Tokyo National Hospital and School of Medicine, Keio University
  • ICHIKAWA YOICHI
    Department of Medicine, the Second Tokyo National Hospital and School of Medicine, Keio University

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  • ACTH Secretion during Sleep in a Patient with Nelson's Syndrome
  • ACTH secretion during sleep in a patien

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Plasma ACTH determinations were made by radioimmunoassay, every 10 min for 8 hours during sleep in a patient with Nelson's syndrome. The plasma ACTH concentrations were relatively stable, fluctuating in a narrow range. It is strongly suggested that the pituitary tumor itself was secreting ACTH in an autonomous manner and it is concluded that a neuronally initiated program of ACTH secretion, was absent in the present patient with Nelson's syndrome.

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