Discovery of Novel Thieno[2,3-d]pyrimidin-4-yl Hydrazone-Based Cyclin-Dependent Kinase 4 Inhibitors: Synthesis, Biological Evaluation and Structure-Activity Relationships

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抄録

The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chemical stability. Furthermore, by focusing on the optimization at the C-4′ position of the thiazole ring and the C-6 position of the thieno[2,3-d]pyrimidine moiety, compound 35 has been identified with efficacy in a xenograft model of HCT116 cells. In this paper, the potency, selectivity profile, and structure–activity relationships of our synthetic compounds are discussed.

収録刊行物

  • Chemical and Pharmaceutical Bulletin  

    Chemical and Pharmaceutical Bulletin 59(8), 991-1002, 2011 

    公益社団法人 日本薬学会

各種コード

  • NII論文ID(NAID)
    130000960931
  • NII書誌ID(NCID)
    AA00602100
  • 本文言語コード
    EN
  • ISSN
    0009-2363
  • NDL 記事登録ID
    11174305
  • NDL 雑誌分類
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-D167
  • データ提供元
    NDL  J-STAGE 
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