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- Nomoto Keitaro
- Anti-Aging Medical Research Center and Medical Fuzzy Research Center, Graduate School of Life and Medical Sciences Doshisha University
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- Arita Seizaburo
- Anti-Aging Medical Research Center and Medical Fuzzy Research Center, Graduate School of Life and Medical Sciences Doshisha University
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- Yonei Yoshikazu
- Anti-Aging Medical Research Center and Medical Fuzzy Research Center, Graduate School of Life and Medical Sciences Doshisha University
書誌事項
- タイトル別名
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- Development of a Model of Functional Endocrine Age in Japanese People -Serum Dehydroepiandrosterone-sulfate (DHEA-s) Concentration as an Index of Aging-
- -Serum Dehydroepiandrosterone-sulfate (DHEA-s) Concentration as an Index of Aging-
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抄録
Objective: As the concentrations of some hormones are known to decrease with age, the aim of the present study was to develop a method to predict the functional age of the endocrine system.<br>Methods: We retrospectively examined data for blood serum or plasma hormone concentration from 3,313 healthy Japanese (2,006 men and 1,307 women, aged 40-79 years) who gave blood samples between 2005 and 2009. Data for DHEA-s, insulin-like growth factor (IGF-I), cortisol, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were analyzed, and the correlation between concentration of each hormone and age was calculated. In a second stage, data were grouped in 10-year age intervals, subjected to one-way analysis of variance (ANOVA) and evaluated using Tukey’s post-hoc test.<br>Results: In both men and women, TSH was positively correlated with age. IGF-I, DHEA-s and cortisol were negatively correlated with age; in men, age was negatively correlated with FT3. Although correlation coefficients (r) and significance levels differed between sexes and hormones, DHEA-s concentration was highly correlated with age and declined with age in both men and women. An age-structured model was developed from the regression of mean DHEA-s concentration and median age of each group. The confidence limits for the regression were small and imply that the predictions from the model are accurate.<br>Conclusion: We developed an age-structured model of age related to serum DHEA-s concentration. It may be useful as an index for evaluating the functional age of the endocrine system in Japanese men and women.
収録刊行物
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- ANTI‐AGING MEDICINE
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ANTI‐AGING MEDICINE 8 (5), 69-74, 2011
一般社団法人 日本抗加齢医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205296301696
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- NII論文ID
- 130000968242
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- ISSN
- 18822762
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 使用不可