A Patient with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Polyangiitis Who Developed Sensorineural Hearing Loss and Scleritis
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- Okura Takafumi
- Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
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- Miyoshi Ken-ichi
- Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
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- Jotoku Masanori
- Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
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- Enomoto Daijiro
- Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
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- Irita Jun
- Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
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- Nagao Tomoaki
- Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
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- Ito Ryoji
- Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
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- Higaki Jitsuo
- Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan
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抄録
A 70-year-old woman was admitted to our hospital because of sudden hearing loss. She was treated with intratympanic dexamethasone, but her hearing impairment progressed. After admission, she developed scleritis of her left eye. Laboratory findings included elevated white blood cell count and C-reactive protein level, microhematuria, and proteinuria. Serology was positive for myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA), but negative for proteinase 3 (PR3)-ANCA. Renal biopsy revealed a single glomerulus with extensive glomerular tuft necrosis, indicating necrotizing vasculitis. She was diagnosed with MPO-ANCA-associated polyangiitis. ANCA-related polyangiitis should be considered in the differential diagnosis of sudden deafness or scleritis.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 50 (16), 1725-1728, 2011
一般社団法人 日本内科学会