Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig

• Maekawa Hitoshi

  Department of Otolaryngology, National Defense Medical College, Japan

• Matsunobu Takeshi

  Department of Otolaryngology, National Defense Medical College, Japan

• Satoh Yasushi

  Department of Anesthesiology, National Defense Medical College, Japan

• Kurioka Takaomi

  Department of Otolaryngology, National Defense Medical College, Japan

• Nakamura Asako

  Research Laboratories, Toyama Chemical Co., Ltd., Japan

• Iwakami Noboru

  Research Laboratories, Toyama Chemical Co., Ltd., Japan

• Shiotani Akihiro

  Department of Otolaryngology, National Defense Medical College, Japan

抄録

T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer’s disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotrauma in guinea pigs treated with rapidly intense pressure change. Sustained oral administration of T-817MA significantly reduced the extent of auditory threshold shifts and outer hair cell loss, indicating that T-817MA attenuates the intense pressure–induced cochlear damage that accompanies inner ear barotrauma via antioxidative activity.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 117 (1), 67-70, 2011

  公益社団法人 日本薬理学会

キーワード

• T-817MA
• inner ear barotrauma
• free radical

詳細情報

• CRID: 1390282680155449600
• NII論文ID: 10029896029
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.11033sc
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 11243237
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11243237
• Web Site: https://search.jamas.or.jp/link/ui/2012227836
• 本文言語コード: en
• データソース種別:
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