Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA - Benzodiazepine Receptor Complex

• Egashira Nobuaki

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Pharmacy, Kyushu University Hospital, Japan

• Nogami Ai

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

• Iwasaki Katsunori

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

• Ishibashi Ayumi

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

• Uchida Naoki

  Department of Psychiatry, Fukuoka University School of Medicine, Japan

• Takasaki Kotaro

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

• Mishima Kenichi

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

• Nishimura Ryoji

  Department of Psychiatry, Fukuoka University School of Medicine, Japan

• Oishi Ryozo

  Department of Pharmacy, Kyushu University Hospital, Japan

• Fujiwara Michihiro

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

抄録

In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABA_A – benzodiazepine receptor complex, but not 5-HT_1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 116 (3), 316-320, 2011

  公益社団法人 日本薬理学会

キーワード

• sleep
• social isolation
• Yokukansan

詳細情報

• CRID: 1390001205181523840
• NII論文ID: 10029895343
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.11079sc
• COI: 1:CAS:528:DC%2BC3MXpslGntr4%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 11162151
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11162151
• Web Site: https://search.jamas.or.jp/link/ui/2012103630
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可