Irrelevance between the Induction of Anti-Campylobacter Humoral Response by a Bacterin and the Lack of Protection against Homologous Challenge in Japanese Jidori Chickens

• OKAMURA Masashi

  Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine

• TOMINAGA Ayumi

  Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine

• UEDA Michihiro

  Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine

• OHSHIMA Rumiko

  Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine

• KOBAYASHI Masahide

  Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine

• TSUKADA Mari

  Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine

• YOKOYAMA Eriko

  The Chemo-Sero-Therapeutic Research Institute

• TAKEHARA Kazuaki

  Laboratory of Veterinary Hygiene, Tokyo University of Agriculture and Technology

• DEGUCHI Kazuhiro

  The Chemo-Sero-Therapeutic Research Institute

• HONDA Takashi

  The Chemo-Sero-Therapeutic Research Institute

• NAKAMURA Masayuki

  Research Institute for Animal Science in Biochemistry & Toxicology

抄録

On-farm vaccination of chickens against Campylobacter jejuni is considered a potentially effective countermeasure to decrease campylobacteriosis via consumption of contaminated chicken meat, but is not yet available. In this study, 2 groups of Jidori chicks were immunized subcutaneously with a formalin-killed C. jejuni with 2 different adjuvants. Other chicks served as the unvaccinated control group. Both vaccines induced high levels of anti-Campylobacter IgG but did not decrease bacterial excretion in cecal droppings and bacterial load in the liver and spleen after oral challenge with 10⁵ CFU of the homologous strain. Further study is needed to address the observed irrelevance and to develop a novel effective vaccine against C. jejuni.<br>

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 74 (1), 75-78, 2012

  公益社団法人 日本獣医学会

キーワード

• <i>Campylobacter jejuni</i>
• humoral immune response
• killed vaccine

詳細情報

• CRID: 1390282681404588032
• NII論文ID: 130001032838
• DOI: 10.1292/jvms.11-0286
• ISSN: 13477439
• ISSN: 09167250
• Web Site: http://www.jstage.jst.go.jp/article/jvms/74/1/74_11-0286/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012173848
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可