各種肝疾患における肝内色素輸送蛋白の臨床的研究

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  • COMPARISON OF HUMAN LIGANDIN WITH ACIDIC Z PROTEIN IN PATIENTS WITH VARIOUS LIVER DISASES

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Human ligandin and acidic Z protein concentrations were quantitated by radioimmunoassay in sera and liver supernatant obtained from controls and patients with liver diseases. Serum Z protein values were statistically correlated with serum ligandin in patients with liver cirrhosis (r=0.57 p<0.01)(39 samples), but not in acute hepatitis (r=0.35)(23 samples) and chronic hepatitis (r=0.197)(37 samples). Serum concentrations of Z protein were all decreased in hyperbilirubinemic patients (Gilbert's Syndrome 5 pts., Dubin Johnson Syndrome 2 pts., Rotor hyperbilirubinemia 1 pts.). Liver ligandin and Z protein concentrations were decreased generally in various liver diseases.

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