胃粘膜腸上皮化生の進展に関する酵素学的ならびに病理組織学的研

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  • ENZYME AND MORPHOLOGICAL STUDIES ON THE DEVELOPMENT OF INTESTINAL METAPLASIA IN HUMAN STOMACH

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Detection of intestinal metaplasia was performed by T es-tape method. Two types of intestinal metaplasia were recognized. Type I, so called complete type, in which sucrase and trehalase activities were present, was frequently observed in older persons but a few in younger ones. Type II, so called incomplete type, in which sucrase was present but trehalase was absent, was frequently observed in younger persons. Complete type metaplasia, which was observed in the intermediate zone of the stomach, contained well-developed brush border, many Paneth cells and goblet cells, histologically. While, in incomplete type metaplasia, poorly-developed brush border, a few Paneth and goblet cells, intracellular mucous in epithelial cells and double structure which means coexsistence of metaplastic glands and pyloric glands, were present.<br>Results suggested that intestinal metaplasia developed from incomplete type to complete one, and complete metaplasia may have occurred from intermediate zone.

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