書誌事項
- タイトル別名
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- The histological and functional studies of experimental gastritis in rats.
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抄録
The influence of taurocholate sodium (TCA) to rat gastric mucosa has been argued very much in the etiology of experimental gastritis. One hundred and twenty one Wistar male rats, weighing 150gm to 200gm, were placed in wire bottom cages and fed stock diet and 5mM TCA fluid supplied ad libitum.<br>The animals were divided into 6 groups composed from the group treated with TCA for 1 month (A), group for 2 months (B), group for 3 months (C), group for 6 months (D), group for 10 months (E), and the control without treated (F).<br>In these groups, gastric mucosal blood flow by means of hydrogen gas clearance method, potential difference (PD), and gastric mucosal pH were measured, and then these items were compared also with histological findings by HEstain, Azanstain and PASstain. Generative zone (G-zone) of rat gastric mucosa was studied by autoradiography, and the length of the glandular portion and tubular portion were measured. Atrophic gastritis showing chronic inflammatory cell infiltration, the shortening length of the glandular portion, the thinning of the epithelium was not clearly formed in this study, but gastritis was shown histologicaly. Blood flow decreased significantly (p<0.05) in C, D, E groups. PD did not change significantly, while pH slightly increased in C, E groups.<br>It is concluded that gastric mucosal blood flow decreased prior to induction of atrophic gastritis treated with TCA.
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 83 (1), 7-16, 1986
一般財団法人 日本消化器病学会
