胆嚢癌の組織発生に関する病理学的研究　Ｉ　　胆嚢癌に見出される腸上皮化生

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  • Pathological study on the histogenesis of the gallbladder carcinoma. Intestinal metaplasia detected in the gallabadder carcinoma.
  • Intestinal Metaplasia detected in the Gallabadder Carcinoma
  • 第1報: 胆嚢癌に見出される腸上皮化生

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The presence of intestinal epithelial metaplasia and endocrine cells was investigated in the mucosa of gallbladder carcinoma. The material consisted of 38 gallbladder carcinomas, all confined to the wall of gallbladder. Areas of intestinal metaplasia within the tumor were found in 25 cases, and those in the mucosa surrounding the tumor were also found in 25 cases. Somatostatin-immunoreactive cells within the tumor were detected in 6 cases, and those outside the tumor in 8 cases. Gastrin-immunoreactive cells within the tumor were detected in none, and those outside the tumor in 5 cases. It seems difficult t oclarify the significance of intestinal metaplasia for the evolution of gallbladder carcinoma from analysis merely of the incidence of intestinal metaplastic changes within or outside the cancerous foci.

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