<sup>131</sup>I-トリオレイン消化吸収試験および<sup>131</sup>I-オレイン酸吸収試験に関する臨床的検討

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  • Standard Methods of <sup>131</sup>I-Triolein Test and <sup>131</sup>I-Oleic Acid Test for Lipid Absorption Study, and their Clinical Investigation

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There had been many reports on the lipid digestion-absorption tests with 131I-triolein and 131I-oleic acid. However, the standard methods of the absorption tests had not been established and there remained many problems to resolved. Several problems were investigated by the authors. The standard methods of both tests were established and the normal ranges (and abnormal value) were settled.<br>The standard methods of 131I-triolein test and 131I-oleic acid test were performed on the patients with malabsorption syndrome, such as secondary malabsorption and maldigestive malabsorption, as well as cholecystectomized, gastrectomized, hepatopathic and diabetic patients. The data were summarized and the following results were obtained.<br>1) The Lugol thyroid blockade is necessary.<br>2) The fecal excretion ratio is more reliable and useful than the blood radioactivity.<br>3) It is recommended that 1ml per killogram body weight of cold meal (peanut oil 20: water 20: tween-80 1.5) shoud be given for 131I-triolein test, and 0.5ml per Kg body weight of clod meal (oleic acid 20: water 20: tween-80 1.5) should be given for 131I-oleic acid test.<br>4) The normal value of the fecal excretion is less than 2.0%. The border-line value is 2.1-4.0%. The abnormal value is more than 4.1%.<br>5) The difference of the value between control groups and abnormal groups is statistically significant.<br>6) Impaired function of lipid digestion-absorption is obviously detected by the absorption tests, but they are not specific for the causative disease.<br>7) Cholecystectomized group revealed marked impairement of lipid digestion-absorption conpared as control group, but the no difference was seen between cholecystectomized group and the cholecystopathic group.<br>8) Among the gastrectomized, the impairement of the lipid absorption was marked in totally gastrectomized group, moderate in BII group, and slight in BI group.<br>9) Hepatopathic patient showed impaired lipid digestion-absorption by 131I-triolein test as well as diabetic patient. The impairement was severer when a patient had both disease. However, there was no definite tendency in the hepatopathic or diabetic patient in 131I-oleic acid test.

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