SAMP8大脳に発現するアルツハイマー病関連タンパク質において検出されたD-アミノ酸量の増加

DOI Web Site 参考文献28件

書誌事項

タイトル別名
  • The Increase of D-Amino Acids in Alzheimer′s Disease-Related Proteins Isolated from the Brains of SAMP8 Mice
  • The increase of D amino acids in Alzheimer s disease related proteins isolated from the brain of SAMP8 mice

この論文をさがす

抄録

Recently, the presence and function of D-amino acids in mammals, including humans, have been reported. In particular, a relationship between an increase in the D-amino acid content of specific proteins and aging and senescence-related diseases has been proposed. However, this hypothesis remains unproven. Here, we focused on Alzheimer′s disease, a well known senescence-related disease, and used high performance liquid chromatography (HPLC) to analyze the degree of change in the D-amino acid content in the Alzheimer′s disease−elated proteins PP1C, GLRX1 and NF-L. Cerebrums of SAM (senescence-accelerated mice), an animal model of Alzheimer′s disease, were used. Increases in D-serine and D-aspartic acid contents with aging in PP1C were found. PP1C is a catalytic subunit of PP1 (serine/threonine phosphatase 1). Tau, one of the most important molecules involved in Alzheimer′s disease, is a target of PP1C. Hyperphosphorylation of Tau is thought to be a trigger of Alzheimer′s disease. Moreover, the involvement of PP1C in cognitive function and memory, independently of dephosphorylation of Tau, has been suggested. The results of this study suggest that substitution of L-amino acids with D-amino acids alters the physical properties of PP1C, and this, in turn, causes its malfunction, which may lead to the onset of Alzheimer′s disease.

収録刊行物

参考文献 (28)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ