Ｍｅｌａｎｏｍａ　ａｓｓｏｃｉａｔｅｄ　ｈｙｐｏｐｉｇｍｅｎｔａｔｉｏｎ　　Ｍｅｌａｎｏｍａ　ａｓｓｏｃｉａｔｅｄ　ｈｙｐｏｐｉｇｍｅｎｔａｔｉｏｎを生じた３例の悪性黒色腫

DOI 被引用文献1件 参考文献20件

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  • Melanoma associated hypopigmentation. Three cases of malignant melanoma which caused Melanoma associated hypopigmentation.

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The significance of the association between the appearance of hypopigmentation in patients with melanoma and the prognosis is still not clear. It was postulated that, in melanoma, an immune response is responsible for the destruction of the malignant as well as the normal pigmented cells, and that the eventual development of hypopigmented vitiligo-like patches in melanoma patients improves their prognosis. We report clinical and histological results in three patients with melanoma and widespread hypopigmented vitiligo-like patches. In the hypopigmented patches DOPA-reaction-positive basal melanocytes became far fewer than in the normal surrounding skin. Also, Mel-5-positive basal melanocytes became fewer than in the normal surrounding skin and the residual melanocytes showed long dendrites.

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