B細胞リンパ腫を合併したparaneoplastic pemphigusの1例
書誌事項
- タイトル別名
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- A case of paraneoplastic pemphigus associated with B cell lymphoma
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We report a 42-year-old man with paraneoplastic pemphigus who developed severe oral mucosal ulceration and pneumonia. Computed tomography of the abdomen demonstrated a mass, and B cell lymphoma was diagnosed by a celiac lymph node biopsy. The patient's serum was positive for anti-desmoglein 1 and 3 antibodies by enzyme-linked immunosorbent assay. Skin biopsies revealed epidermal vacuolization and suprabasal cleft formation. IgG deposition was observed in intercellular spaces of the epidermis and C3 was also positive along the basement membrane zone on direct immunofluorescence.<br>An indirect immunofluorescence analysis using normal human skin as its substrate showed antiintracellular IgG antibodies at a titre of 1 in 160, which also reacted with transitional epithelia of rat urinary bladder. The patient's serum immunoprecipitated antigens at 210-kDa envoplakin and 190-kDa periplakin. Prednisolone, cyclosporin and topical steroids were used for mucosal lesion without remarkable improvement. Finally, progressive respiratory failure with clinical features of bronchiolitis obliterans was the cause of death in this case. [Skin Cancer (Japan) 2008; 23: 11-16]
収録刊行物
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- Skin Cancer
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Skin Cancer 23 (1), 11-16, 2008
日本皮膚悪性腫瘍学会
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詳細情報 詳細情報について
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- CRID
- 1390001204336710400
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- NII論文ID
- 130001078850
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- ISSN
- 18843549
- 09153535
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可