Plasma Hepatocyte Growth Factor Elevation May Be Associated with Early Metastatic Disease in Primary Lung Cancer Patients
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- Hosoda Hiroshi
- Division of Thoracic Surgery, Hokushin General Hospital, Nishi Nakano, Nagano, Japan
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- Izumi Hiroyuki
- Division of Thoracic Surgery, Hokushin General Hospital, Nishi Nakano, Nagano, Japan
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- Tukada Yoshikazu
- Division of Respiratory Disease, Hokushin General Hospital, Nishi Nakano, Nagano, Japan
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- Takagiwa Jun
- Division of Respiratory Disease, Hokushin General Hospital, Nishi Nakano, Nagano, Japan
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- Chiaki Tomoshige
- Division of Respiratory Disease, Hokushin General Hospital, Nishi Nakano, Nagano, Japan
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- Yano Makoto
- Department of Thoracic Surgery, Musashino Red Cross Hospital, Musashino, Tokyo, Japan
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- Arai, Hirokuni
- Department of Thoracic and Cardiovascular Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
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抄録
Purpose: Hepatocyte growth factor (HGF), a ligand of the c-met proto-oncogene, exhibits activating effects on human lung cancer both in vitro and in vivo. However, few studies have reported the correlations between concentration changes of blood HGF and postsurgical prognosis.<br>Methods: We evaluated whether surgery-related blood HGF elevation has prognostic significance in patients with surgically resected non-small cell lung cancer. We examined blood HGF concentration, c-met expression, and postoperative prognosis of 25 cases of primary resected, non-small cell lung cancer.<br>Results: We divided the patients into 2 groups according to receiver operating characteristics curve analysis using 7.2 ng/mL as the cut-off value of blood HGF concentration. Survival curve analysis revealed that patients with a high level of HGF (over the cutoff value) exhibited a poor prognosis of metastatic disease, compared to those in the low-level group after curative surgery (log rank test, P = 0.020; Wilcoxon test, P = 0.016).<br>Conclusion: Elevation of HGF in plasma may be an important prognostic factor for early metastatic disease in patients with primary lung cancer. Moreover, inhibition of HGF elevation may have therapeutic effects on early distant metastasis of lung cancer.
収録刊行物
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- Annals of Thoracic and Cardiovascular Surgery
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Annals of Thoracic and Cardiovascular Surgery 18 (1), 1-7, 2012
Annals of Thoracic and Cardiovascular Surgery 編集委員会
