上気道炎症に対する新たな局所治療薬としてのヘパリンの可能性

DOI 機関リポジトリ 参考文献66件

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  • The inhibitory effects of heparin on the upper airway inflammation

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Heparin is a member of a family of polyanionic polysaccharides called glycosaminoglycans, and is one of the most important anticoagulant drugs. Heparin also has a variety of anti-inflammatory functions, and is clinically used as an anti-inflammatory drug. In the lower airways, it has been reported that heparin attenuated eosinophil infiltration and Muc5ac mRNA expression in rat model of asthma, and inhaled heparin is effective for the treatment of patients with asthma. However, little is known about the regulatory effects of heparin on the upper airway inflammation. <br> We have examined the in vivo and in vitro effects of heparin on mucus hypersecretion in airway epithelial cells. Intranasal instillation with low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) significantly inhibited lipopolysaccharides (LPS)-induced and antigen-induced mucus hypersecretion in rat nasal epithelium. Mucosal infiltration of neutrophils and eosinophils were also significantly attenuated. The in vitro effects of heparin on secretion of mucin and cytokines were examined using cultured airway epithelial cells (NCI-H292). LMWH and UFH significantly inhibited TNF-α-induced secretion of mucin (MUC5AC) and IL-8. These results indicated that local administration with heparin may provide a new therapeutic strategy for upper airway inflammation.<br>

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