Maternal Exposure to Low Doses of DES Altered mRNA Expression of Hepatic Microsomal Enzymes in Male Rat Offspring

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  • NISHIKAWA Osamu
    Department of Anatomy II, School of Veterinary Medicine, Azabu University
  • ARISHIMA Kazuyoshi
    Department of Anatomy II, School of Veterinary Medicine, Azabu University
  • KOBAYASHI Tetsuo
    Department of Anatomy II, School of Veterinary Medicine, Azabu University
  • SHIRAI Mitsuyuki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University
  • MURAKAMI Masaru
    Department of Molecular Biology, School of Veterinary Medicine, Azabu University
  • SAKAUE Motoharu
    Department of Anatomy II, School of Veterinary Medicine, Azabu University
  • YAMAMOTO Masako
    Department of Anatomy II, School of Veterinary Medicine, Azabu University

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Our previous studies demonstrated that prenatal diethylstilbestrol (DES) treatment disrupts steroidogenesis but induces high-level expression of androgen receptor (AR) mRNA to inhibit the disruption of spermatogenesis. This study examined which prenatal DES treatment influenced hepatic microsomal enzymes, CYP3A1, CYP2B1/2, CYP2C11, UGT2B1 (UDP-glucuronosyltransferase 2B1), and IGF-1 (insulin-like growth factor-1), in male rat offspring. DES treatment decreased the mRNA expression levels of CYP3A1 and CYP2B1/2, but did not alter the expression of CYP2C11. At 6 weeks, DES treatment increasd the mRNA expression levels of UGT2B1 and IGF-1. These results suggest that prenatal DES treatment alters two hepatic enzymes (CYP3A1 and CYP2B1/2) and IGF-1 mRNA expression levels to counteract the low level of testosterone, but this disrupted UGT2B1 mRNA expression reduces the testosterone level.<br>

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