Ｃｅｆｏｄｉｚｉｍｅ（ＣＤＺＭ，ケニセフ）のヒト口腔組織移行に関する薬動力学的検討

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  • Pharmacokinetic studies on the distribution of cefodizime(CDZM) to oral tissues of man.

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To study the feasibility of employing cefodizime (CDZM) in the field of oral surgery, a pharmacokinetic analysis was performed for CDZM concentrations in the oral tissues after intravenous injection of 1g CDZM in 26 patients.<BR>The following results were obtained:<BR>1) The half-life of CDZM in serum was calculated to be 2.64 hours.<BR>2) The peak concentrations of CDZM were 13.03 μg/g in the gum, 4.84 μg/g in the bone and 17.06 μg/g in the cyst wall. The AUC of CDZM in oral tissue to that in serum was 12.53% in the gum, 3.26% in the bone, and 8.23% in the cyst wall.

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