口腔前癌病変，前癌状態の悪性化能に関する組織学的検討

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  • Histological evaluation of potentiality of malignant transformation in oral precancerous lesions and precancerous conditions.

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The relationship between epithelial dysplasia and malignancy potential of oral precancerous lesions and precancerous conditions (PL & PC) was histologically examined. Histological epithelial dysplasia was investigated in 41 cases of leukoplakia and erythroplakia (L & E) 39 of lichen planus (LP), 34 of dysplastic epithelium adjacent to squamous cell carcinomas (SCC), and 8 of PL & PC which subsequently became SCC. Dysplastic score was assigned based on the dysplastic criteria of the WHO (1978). The average dysplastic scores were 2.9 ± 2.7 points in L & E, 2.2 ± 1.2 in LP 5.6 ± 2.3 in PL & PC which subsequently become SCC, and 6.3 ± 2.7 in dysplastic epithelium adjacent to SCC. Thus, the degree of dysplasia was obviously associated with the potentiality for malignant transformation. Important dysplastic characteristics were an increased nucleo-cytoplasmic ratio, dropshaped rete processes, cell crowding, pleomorphic cells and nuclei, and hyperchromatic nuclei. The methods used in this study were useful in evaluating the malignancy potential of oral lesions, and provided diagnostic suggestions.

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