唾液腺多形性腺腫におけるリゾチームとラクトフェリンの局在についての研究

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  • Immunohistochemical localization of lysozyme and lactoferrin in salivary pleomorphic adenomas.

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It has been reported that lysozyme and lactoferrin as antibacterial factors havedefence mechanisms against oral microrganisms. The present study describes that immunohistochemical localization and origin of these substances in salivary glands, in addition their distribution patterns in salivary pleomorphic adenomas. Histogenesis of pleomorphic adenoma was also evaluated. A total 147 cases of salivary pleomorphic adenomas were examined immunohistochemically with the use of the PAP method, as well as histologically with H & E stain.<BR>1. Lysozyme staining was expressed only in intercalated duct cells of major salivary gland, whereas it was positive in demilune and serous cells and intralobular duct cells of minor gland. Distribution of lysozymes was different in major and minor salivary glands. Lactoferrin reaction was found in serous acinor cells and ductal segments with irregular fashions.<BR>2. Pleomorphic adenomas showed that 14%(21/147) of the cases showed positive staining for lysozyme, and lysozyme was confined to luminal tumor cells. Lactoferrin reaction in the tumor indicated 3 different distribution patterns; 1) Luminal cells positive type 51%(75/147), 2) outer cell positive 3%(4/147) and both luminal and outer cells positive 5%(7/147). Plasmacytoid cells of modified myoepithelium were occasionally positive for lactoferrin (5%). In the stromal cells, histiocytes showed positive reactions for both lysozyme and lactoferrin.<BR>3. Modified or neoplastic myoepithelial cells were usually devoid of both the substances, however in a few instances, strong lactoferrin reactivity was found in myoepithelioma cells.<BR>4. Histomorphological features and immunohistochemical detectable lysozyme and lactoferrin were evaluated and compared in pleomorphic adenomas and in the normal salivary glands, and histogenesis of pleomorphic adenomas was discussed in terms of immunohistochemical patterns.

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