ヒト唾液腺腫ようの免疫組織化学的研究

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  • Immunohistochemical study on human salivary gland tumors.

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Histogenesis of the salivary gland tumor is controversial due to the variety of histopathologic features.Recently, localization of various antigens and cytoskeletal filamentous proteins have been morphologically identified, as the immunohistochemistry developed.<BR>In the present study, 70 cases of salivary gland tumors removed surgically in our hospital were stained immunohistochemically.Antibodies used for immunostaining were S-100 a, lactoferrin (LF), secretory component (SC), CEA, keratin, prekeratin, myosin as the polyclonal antibody, and S-100 b, PKK-1, vimentin as the monoclonal antibody.<BR>Positive immunostaining for S-100 a was only observed in pleomorphic adenoma. All of chondroid cells and some of spindle cells, epithelial tumor cells showed intense immunoreactivity for S-100 a.<BR>LF was predominantly positive in pleomorphic adenomas and was stained in a few cases of adenolynphoma, adenoid cystic carcinoma and adenocarcinoma.SC reacted positively not only in LF positive tumors but also in 50% of mucoepider moid tumors.The positive rate for CEA was 22% in benign tumors and 50% in malignant tumors.<BR>Keratin and prekeratin thought to be the epithelial tumor markers were frequently stained in almost all tumors.Myosin-positive cells were localized in some of spindle cells, chondroid cells in pleomorphic adenoma, and also some of undifferentiated polygonal cells in adenoid cystic carcinoma.<BR>According to the immunohistochemical staining pattern, the following results were concluded.<BR>1) S-100 a stained pleomorphic adenoma specifically.<BR>2) Duct-like structure in pleomorphic adenoma retains the function of production of LF and SC in accordance with functional differentiation.<BR>3) Regezi's bicellular theory presents a reasonable explanation of the origin of the salivary gland tumor.

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