大だ液せん，多形性せんしゅの免疫組織化学的研究　　特に組織発生についての検討

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  • Immunohistochemical study of pleomorphic adenoma of major salivary glands - With special emphasis on its histogenesis.
  • With special empbasis on its histogenesis
  • 特に組織発生についての検討

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Picomorphic adcnomas of major salivary glands were examined to determine the nature of the cell within the epithelial elements, the myxoid stroma, and cartilage by applying inununohistochemical technique. The nroplastic myoepithelial cells were divided into differentiated (actin-containing) and undifferentiated (S-100 protein-and prekeratin-containing) cell types. Tumor-associated mesenchyms (myxoid and chondroid tissues) may be related to nervous tissue, because these tissues were positively stained with S-100 protein antibody, glial fibrillary acidic protein antibody, and γ-neuron specific enolase antibody. Thus, it seems reasonable to postulate that the parent cells of the pleomorphic adcnomas may have a common origin with those derived from embryonic ectoderm (epithelial components) and neural crest (inesenchymal components).

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