Synthesis and Assignment of Novel (125I)-Labeled 1.ALPHA.,25-Dihydroxyvitamin D3 Derivatives.

• TANABE Miyuki

  Research Laboratories, Toyo Jozo Co., Ltd.

• HARADA Masaya

  Research Laboratories, Toyo Jozo Co., Ltd.

• ODAWARA Fumitomo

  Research Laboratories, Toyo Jozo Co., Ltd.

• IKUTA Shigeru

  Research Laboratories, Toyo Jozo Co., Ltd.

• NAKAGAWA Nobuaki

  Research Laboratories, Toyo Jozo Co., Ltd.

• OTANI Masaru

  Research Laboratories, Toyo Jozo Co., Ltd.

抄録

This paper describes the synthesis and structural assignment of novel ¹²⁵I-l α, 25-dihydroxyvitamin D₃ derivatives (1a) and (lb) labeled with ¹²⁵I-Bolton-Hunter reagent [N-succinimidyl 3-(4-hydroxy-3-iodo [¹²⁵I] phenyl)propionate] (1), which is known as a protein-labeling reagent, as tracers for radioimmunoassay (RIA). The radiospecific activities of these tracers (1a) and (lb) were calculated as 2, 200 Ci/mmol (81.4TBq/mmol).

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 37 (2), 139-147, 1991

  一般財団法人 学会誌刊行センター

キーワード

• 1α, 25-dihydroxyvitamin D₃
• iodo[¹²⁵I]-labeled 1α
• 25-dihydroxyvitamin D₃
• ¹²⁵I-Bolton-Hunter reagent
• anti-1α
• 25-dihydroxyvitamin D₃ sheep serum
• radiommunoassay (RIA)

詳細情報

• CRID: 1390282681300343680
• NII論文ID: 130001369177
• DOI: 10.3177/jnsv.37.139
• ISSN: 18817742
• ISSN: 03014800
• PubMed: 1919801
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可