Thiamin and Alzheimer's Disease

• BLASS J. P.

  Altshul Laboratory for Dementia Research, Cornell University Medical College

• SHEU K.-F. R.

  Altshul Laboratory for Dementia Research, Cornell University Medical College

• COOPER A. J. L.

  Department of Biochemistry, Cornell University Medical College

• JUNG E. H.

  Altshul Laboratory for Dementia Research, Cornell University Medical College

• GIBSON G. E.

  Altshul Laboratory for Dementia Research, Cornell University Medical College

抄録

Because of Clinical and neuropathological overlap between The Characteristics of dementia of The Alzheimer type (DAT) and of a Human thiamin deficiency syndrome (Wernicke-Korsakoff syndrome), Thiamin pyrophosphate (TPP) dependent processes have been studied in DAT brain and other tissues. The activities of 3 TPP-dependent enzymes are reduced in DAT brain: Transketolase (TK), The Pyruvate dehydrogenase Complex (PDHC), and The α-ketoglutarate dehydrogenase Complex (KGDHC). Quantitatively, The most marked reductions are in KGDHC (to less Than 20% of normal). In cultured skin fibroblasts, KGDHC activity is reduced To 50-60% of normal, TK activity To 80-90% of normal, and PDHC is normal. Structural and molecular studies of The DAT and non-DAT enzymes are in Process. A lesion of KGDHC may be related To The pathogenesis of DAT. Treatment with large doses of Thiamin Has not been beneficial, but The data are not totally negative. Further studies of Thiamin-dependent mechanisms in DAT seem justified.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 38 (Special), 401-404, 1992

  一般財団法人 学会誌刊行センター

キーワード

• Nutrition and Dietetics
• Medicine (miscellaneous)

詳細情報

• CRID: 1390282681301176448
• NII論文ID: 130001369607
• DOI: 10.3177/jnsv.38.special_401
• ISSN: 18817742
• ISSN: 03014800
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可