Effects of Antioxidants on the Oxidative Susceptibility of Low-Density Lipoprotein.

DOI Web Site PubMed 被引用文献19件
  • HIRANO Reiko
    Division of Clinical Nutrition, National Institute of Health and Nutrition Institute of Environmental Science for Human Life, Ochanomizu University
  • KONDO Kazuo
    Division of Clinical Nutrition, National Institute of Health and Nutrition
  • IWAMOTO Tamami
    Division of Clinical Nutrition, National Institute of Health and Nutrition
  • IGARASHI Osamu
    Institute of Environmental Science for Human Life, Ochanomizu University
  • ITAKURA Hiroshige
    Division of Clinical Nutrition, National Institute of Health and Nutrition

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  • Effects of Antioxidants on the Oxidativ

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An important event in the pathogenesis of atherosclerosis is believed to be the oxidative modification of low-density lipoprotein (LDL) initiated by a free radical-driven lipid peroxidation process. Vitamin E acts as a lipophilic chain-breaking antioxidant, while water-soluble chain-breaking antioxidants such as vitamin C or uric acid suppress the oxidation of LDL initiated by aqueous radicals. In this study, we established a new method of measuring the lag time of inhibited lipid peroxidation using the lipophilic azo radical initiator V-70: 2-2'-azobis(4-methoxy-2, 4-dimethylvaleronitrile) and investigated in vitro the suscepti-bility of LDL to oxidation using this method when lipid- and water-soluble antioxidants were added. When the lipid-soluble antioxidant, vitamin E, was added to LDL, the lag time was extended whereas a higher dose of vitamin E led to a shortened lag time of V-70-induced lipid peroxidation in LDL. These results suggest that vitamin E radicals (tocopheroxyl radicals) act as prooxidants during the autoxidation of LDL. It was also shown that the shortened lag time induced by higher doses of vitamin E was restored when lipid- and water-soluble antioxidants were added simultaneously, which suggests that vitamin E radicals derived from vitamin E are subsequently reduced by vitamin C to regenerate vitamin E. Thus, the interaction between lipid- and water-soluble antioxidants provides an important function in maintaining LDL resistance to oxi-dation.

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