マウス‐Transfer Factorによる遅延型過敏症反応と感染防御効果

  • 近藤 譲
    名古屋大学医学部附属病態制御研究施設医真菌研究部門
  • 清水 克実
    名古屋大学医学部附属病態制御研究施設医真菌研究部門

書誌事項

タイトル別名
  • Transfer of delayed-type hypersensitivity to Candida albicans or Sporothrix schenkii and protection against experimental candidiasis with murine-Transfer Factor.
  • マウス Transfer Factor ニ ヨル チエンガタ カビンショウ ハ

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Delayed-type hypersensitivity of Candida albicans (C. albicans) or Sporothrix schenkii (S. schenkii) was transferred specifically to nonimmune mice by intraperitoneal injection of dialysate of the spleen cell extract (Transfer Factor; TF) prepared from the immune mice. The mice treated with TF displayed significantly thickened footpads in the footpad swelling test. Morever, the Candida TF-treated mice survived the infection with a lethal dose of C. albicans. Fewer cells of C. albicans were recovered from the lungs and kidneys of the Candida TF-treated mice than from those of the mice treated with the dialysate of the spleen cells from nonimmune mice.

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