Ｃｌｏｓｔｒｉｄｉｕｍ　ｂｕｔｙｒｉｃｕｍによる実験的抗生物質起因性下痢の予防

• 田口 信洋

  千葉大学真核微生物研究センター

• 阿部 章彦

  信州大学医学部第二病理学教室

• 三上 襄

  千葉大学真核微生物研究センター

• 新井 正

  千葉大学真核微生物研究センター

書誌事項

タイトル別名

• Prevention of experimental antibiotic-associated diarrhea by Clostridium butyricum.
• Clostridium butyricum ニ ヨル ジッケンテキ コウセイ

抄録

A golden-hamster model of antimicrobial agent-associated lethal enterocolitis was produced by oral administration of cef atrizine (CFT). In all diarrheal and dead animals, the striking finding at necropsy was enterocolitis in which the cecum and distal ileum were greatly distended with fluid: toxigenic Clostridium difficile was detected at 10⁸ CFU/head or greater. Bacteria-free cecal filtrate and culture filtrate of C. difficile isolated from the cecal contents of diarrheal animals exhibited lethal toxicity to normal hamsters. A single oral administration of CFT (75mg/kg) produced lethal enterocolitis in 17 of 20 animals during a one-month period of observation.<br>Clostridium butyricum Miyairi (CbM), spores, used as an enteroregulator, were investigated for their potential to prevent the lethal enterocolitis in this model. Animals were administrated CbM orally (10⁹ CFU/day) for three consecutive days after CFT challenge, and this prevented death in 16 of 20 animals during one mouth of observation. These results suggest that CbM has a preventive effect against lethal enterocolitis in this model.

収録刊行物

• 日本細菌学雑誌

  日本細菌学雑誌 43 (4), 829-835, 1988

  日本細菌学会

キーワード

• General Medicine

詳細情報

• CRID: 1390282681426150656
• NII論文ID: 130001386129
• NII書誌ID: AN00189800
• DOI: 10.3412/jsb.43.829
• ISSN: 18824110
• ISSN: 00214930
• ISSN: http://id.crossref.org/issn/00214930
• NDL書誌ID: 3200317
• PubMed: 3070066
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3200317
• Web Site: https://search.jamas.or.jp/link/ui/1991056843
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可