Enteropathy-Associated T-Cell Lymphoma Type II Complicated by Autoimmune Hemolytic Anemia

DOI 被引用文献4件 参考文献14件
  • Kato Aiko
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Takiuchi Yoko
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Aoki Kazunari
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Ono Yuichiro
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Arima Hiroshi
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Nagano Seiji
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Tabata Sumie
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Yanagita Soshi
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Matsushita Akiko
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Maruoka Hayato
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Wada Masaya
    Gastroenterology, Kobe City Medical Center General Hospital
  • Imai Yukihiro
    Clinical Pathology, Kobe City Medical Center General Hospital
  • Ishikawa Takayuki
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
  • Takahashi Takayuki
    Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital

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A 74-year-old man was admitted to hospital because of persistent fever, diarrhea, and abdominal pain. CT scanning showed extensive wall thickening of the colon. He was transferred to our hospital because he further developed ascites and paraaortic lymph node swelling. On presentation, he was extremely emaciated with superficial lymph node swelling, ascitic signs, and leg edema. Histological image of a biopsied mesenteric lymph node demonstrated diffuse infiltration of large abnormal T cells. Surface antigen analysis of abnormal cells in the ascites revealed positivity for CD3, CD8, CD56, and weak positivity for CD103. Polymerase chain reaction analysis showed monoclonal rearrangement of the T cell receptor (TCR) gene. The subtype of TCR was αβ. A diagnosis of enteropathy-associated T cell lymphoma (EATL) type II was made. The lymphoma involved the bone marrow. The patient also had severe hemolytic anemia with a positive Coomb's test result. An additional diagnosis for autoimmune hemolytic anemia (AIHA) was made, which was resistant to methylprednisolone therapy. We first treated him with only vincristine in addition to the steroid to avoid acute tumor lysis syndrome ; however, he died of septic shock that occurred soon after vincristine administration. To the best of our knowledge, this may be the first reported case of EATL complicated by AIHA. [J Clin Exp Hematopathol 51(2) : 119-123, 2011]

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