書誌事項
- タイトル別名
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- Studies on blood level of RFP and new administration method of RFP in relation to other anti-tuberculous drugs.
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抄録
It has not been conclusively decided yet which is more effective method to give rifam picin (RFP) before or after breakfast. Conventionally RFP is given with other antituber culous drugs after breakfast by us to avoid gastric side effects, but it is necessary to study the best administration time of RFP in relation to other drugs.<BR>To determine the best administration time of RFP, the serum concentration of RFP were measured by high performance liquid chromatography (HPLC). HPLC was operated by the stuff of Kaken Seiyaku Co., Ltd.<BR>Experiments were done as follows:<BR>(1) RFP was given to the eleven patients either before or after breakfast by the cross-over method. The sample (sera) were taken at 0, 1, 2, 3, 4, 6 and 8 hours after the administration of RFP (Table 1).<BR>(2) The blood levels of RFP were determined in another groups of patients. 6 patients were given RFP before breakfast and 12 patients were given RFP after breakfast. Samples were taken at 0, 2, 4 and 8 hours after the before-breakfast administration, and at 0, 2, 4, 6 and 8 hours after the after-breakfast administration (Table 2).<BR>(3) The blood levels of RFP of 12 patients were followed during 24 hours after the after-breakfast administration. Blood samples were taken at 0, 2, 4, 6, 8, 12 and 24 hours after the administration (Table 3).<BR>Results obtained from these experiments were as follows:<BR>(1) The average of maximal blood concentrations (C max) were almost same in the before-breakfast administration and in the after-breakfast administration.These were 5.3μg/ml and 4.5μg/ml respectively.<BR>(2) The time required for the RFP concentration to reach C max (T max) was 1 to 2 hours in the before-breakfast administration and 3 to 4 hours in the after-breakfast ad ministration. There were greater deviation of C max, T max and AUC (area under curve) in the after-breakfast administration cases than in the before-breakfast administrationcases.<BR>From these results, the before-breakfast administration seems to be slightly more effective. But it is suspicious that such melit is able to overcome the gastric side effect in the before breakfast administration.<BR>(3) The average concentration of RFP during 24 hours after the RFP administration were lower in 5 cases who had discharged tubercule bacilli beyond 3 months than in 5 cases who had discharged it for only 1 to 2 months.<BR>(4) Considering above mentioned results, we give the drugs separately to our in-patients: We give RFP after breakfast to avoid its gastric side effects and other antitubercu lous drugs (I NH and/ or EB) after lunch to attain C max of all drugs at the same time as possible.
収録刊行物
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- 結核
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結核 60 (9), 483-494, 1985
一般社団法人 日本結核病学会