特異的Thromboxane(TX)A2合成酵素阻害剤(E)‐3‐〔p‐(1H‐imidazol‐1‐ylmethyl)phenyl〕‐2‐propenoic acid(OKY‐046)の抗アレルギー作用 (第2報) II~IV型アレルギー反応に対する作用
書誌事項
- タイトル別名
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- Anti-allergic effects of (E)-3-(p-(1H-imidazol-1-ylmethyl)phenyl)-2-propenoic acid (OKY-046), a specific thromboxane(TX) A2 synthetase inhibitor: Effect of OKY-046 on II-IV type allergic reactions.
- トクイテキ Thromboxane TX A2 ゴウセイ コウソ ソガイザイ
- II-IV型アレルギー反応に対する作用
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We studied the effects of OKY-046 on types II, III and IV allergic reactions, as classified by Coombs and Gell. In Type II, OKY-046 at 30-100 mg/kg intraduodenally (i.d.) and at 1-30 mg/kg intravenously (i.v.) inhibited the bronchoconstriction in a dose-dependent manner after Forssman antigen injection. Aspirin (3 mg/kg, i.v.) also suppressed it. OKY-046 (30-100 mg/kg, i.d.) suppressed the increase of TXB2 level in the plasma in a dosedependent manner. However, there was no effect of OKY-046 and aspirin on the decrease in complement activity (CH50), platelets and leukocytes. Additionally, OKY-046 (300 mg/ kg, p.o.) prolonged the survival time following Forssman antigen injection. However, the immune hemolysis reaction was not prevented by OKY-046 (10-6-10-3M). FUT-175 protected against the Forssman shock at 1 mg/kg, i.v. and the in vitro immune hemolysis reaction at 10-5M. In Type III, OKY-046 (300 mg/kg, p.o.) significantly suppressed the direct passive Arthus reaction and immune complex nephritis in rats. There was no effect of OKY-046 on the delayed-type hypersensitive response to picryl chloride in mice. We think that OKY-046 should be a beneficial drug for the treatment of types II and III allergic reactions.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 95 (3), 131-137, 1990
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679247721984
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- NII論文ID
- 130001507018
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK3cXitFSksLo%3D
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- ISSN
- 13478397
- 00155691
- http://id.crossref.org/issn/00155691
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- NDL書誌ID
- 3659469
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- PubMed
- 2141317
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可