書誌事項
- タイトル別名
-
- The effects of nicotinic acid on bilirubin metabolism and its diagnostic significance as nicotinic acid test in various liver disorders
この論文をさがす
抄録
The changes in serum bilirubin levels following intravenous injection of 50 mg of nicotinic acid have been studied in normal subjects and in patients with hepatic disorders.<BR>The followings are the conclusions:<BR>1. This test provides information for the differential diagnosis in terms of increment, peak time and retention of unconjugated bilirubin.<BR>2. Increment of unconjugated bilirubin after this test in patients with Gilbert's syndrome was above 1 mg/ 100 ml, distinctly greater than in patients with unconjugated hyperbilirubinemia unrelated to Gilbert's syndrome.<BR>3. Evidence is presented that the spleen contributes in a large measure to the increase of unconjugated bilirubin after this test.<BR>4. For unknown reasons, prednisolone suppressed the increase of unconjugated bilirubin after this test.<BR>The nicotinic acid test is useful as a tolerance test with endogenous bilirubin, but it should be that the hyperbilinemic curve is consequence of the formation of unconjugated bilirubinin the spleen and its inadequate disposal in the liver.
収録刊行物
-
- 日本消化器病学会雑誌
-
日本消化器病学会雑誌 74 (5), 645-654, 1977
一般財団法人 日本消化器病学会