Clamping-Cortisone潰瘍による諸種抗潰瘍剤の生物検定

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  • The bioassay of various anti-ulcerous drugs by using the Clamping-Cortisone ulcer
  • 特に組織並びに計量的検討

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The curative effects of twelve kinds of drugs which have been used clinically, were tested by using the Clamping-Cortisone ulcer. The results of the studies are summarized as follows.<BR>1) The curative effects of antacids, i.e. sodium bicarbonate (NB) and Alumigel, were 1.5 times greater compared with the natural healing processes of the non treated control ulcer. A characteristic tissue contraction in the group treated with NB was found.<BR>2) The curative effects of the mixed remedies which contained Bentyl, propantheline, glycirrhizin and some antacids, were more remarkable than that of the antacids. This means that the curative effect is raised by mixing the several kinds of the drugs which have different curative action.<BR>3) In the group treated with drugs which showed excellent healing effects, the lineal relationships between the mucosal regeneration and development of the connective tissues was seen. It was found that there are two kinds of drugs which have a contrasting action on the mucosa and the connective tissues. For instance, 4cl-TA promoted chiefly development of the collagen fiber, and Solcoseryl accelerated regeneration of the mucosa.<BR>4) The single use of the antisecretory drugs such as Proglomid and Sulpilid, did not show any distinct curative effect on the ulcer.<BR>5) It is confirmed that the Clamping-Cortisone ulcer is very useful for the bioassay of the curative effect of drugs on the gastric ulcer.

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