書誌事項
- タイトル別名
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- Studies on properties of LDH-binding immunoglobulin in a case of Oxyphenisatin-induced lupoid hepatitis
- 抗LDH単クローン性自己抗体の発見
この論文をさがす
抄録
Total lactate dehydrogenase (LDH) activity in serum from a 64 year-old patient with Oxyphenisatin-induced lupoid hepatitis was 653 W. U.<BR>The serum LDH isoenzyme pattern of this patient showed only a single component which was in the LDH-4, i.e. H1M3position.<BR>A hemolysate of washed red blood cells from this patient revealed normal LDH isoenzyme pattern.<BR>Further investigations showed that the abnormal serum LDH isoenzyme pattern resulted from formation of the macromolecular complex between all of the serum LDH-1, -2, -3, -4 and-5, and M-component (Immunoglobulin G of the kappa class).<BR>Papain-digestion of this M-component proved the LDH-binding capacity to reside only in the Fab fragment.<BR>Although a small number of antigen-binding homogeneous immunoglobillins produced by benign or malignant monoclonal disorders have been described, this is the first report of the presence of anti-LDH monoclonal autoantibody.
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 71 (12), 1249-1255, 1974
一般財団法人 日本消化器病学会