コイの血液凝固機能に及ぼすワルファリン経口投与の影響

• 川津 浩嗣

  宮崎大学農学部水産増殖学科

• 久保埜 和成

  宮崎大学農学部水産増殖学科

• 若林 高明

  エーザイ株式会社動薬事業部

書誌事項

タイトル別名

• Effect of oral administration of warfarin on blood coagulation in the common carp.
• コイの血液凝固機能に及ぼすワルファリン経口投与の影響〔英文〕
• コイ ノ ケツエキ ギョウコ キノウ ニ オヨボス ワルファリン ケイコウ ト

抄録

The anticoagulant effect of potassium warfarin and the antagonistic effect of vitamin K₃ a-gainst warfarin were examined using common carp. Three different dosages of warfarin with and without supplementary vitamin K₃ were orally administered to common carp for 10-14 days, and prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured at in-tervals of 3-7 days. At dosages of 2.0 and 1.0mg/kg/day of warfarin, prolongation of PT and APTT was observed. Supplementation of vitamin K₃ was effective in preventing the prolongation of PT at a dosage of 1.0mg of warfarin, but it was not effective at 2.0mg. On the other hand, supplementation of vitamin K₃ could not prevent prolongation of APTT with any warfarin dosage used, indicating that the antagonistic effect of vitamin K₃ against warfarin is limited to PT.

収録刊行物

• 日本水産学会誌

  日本水産学会誌 57 (4), 619-622, 1991

  公益社団法人 日本水産学会

キーワード

• Aquatic Science

詳細情報

• CRID: 1390282681388213248
• NII論文ID: 130001545287
• NII書誌ID: AN00193422
• DOI: 10.2331/suisan.57.619
• ISSN: 1349998X
• ISSN: 00215392
• NDL書誌ID: 3723436
• Web Site: https://agriknowledge.affrc.go.jp/RN/2010431012
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3723436
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可