慢性関節リウマチ滑膜における細胞性癌遺伝子とサイトカインmRNAの発現
書誌事項
- タイトル別名
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- Proto-oncogene and Cytokine mRNA Expression in the Synovivm of Rheumatoid Arthritis.
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This study investigated the localization of proto-oncogenes and cytokine mRNAs in the synovium of rheumatoid arthritis.<br>Synovial tissues were obtined from patients with rheumatoid arthritis (RA), osteoarthritis (OA), and traumatic arthritis (TA) at the time of Surgery. The sections were processed for in hybridization histochemistry using oligoncleotide probes for IL-1, IL-6, TNF-α, c-fos and c-jun.<br>In the synovium of RA, IL-6mRNAs were expressed strolgly in the lining layer, sublining area and stromal area, while IL-1 mRNAs were detected in the stromal area where cells aggregated. TNF-α mRNAs were expressed in the stromal area, although weakly, Proto-oncogene, c-fos and c-jun mRNAs were expressed in the lining layer, and endoetheliocytes. Other synovial tissues from non-RA patients, the mRNAs were found weakly or were undtectaltable.<br>These results suggest that activated cells in the synovium synthesized cytokines which then stimulate the expression of proto-oncogene. These phenomena may play an important role in the joint destruction seen in RA.
収録刊行物
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- 整形外科と災害外科
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整形外科と災害外科 42 (3), 980-982, 1993
西日本整形・災害外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204933010432
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- NII論文ID
- 130001632173
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- ISSN
- 13494333
- 00371033
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可